Pengaruh Ekstrak Etanol Daun Sukun (Artocarpus Communis) Terhadap Radang Lokal Dan Il-6 Pada Mencit Model Gout Arthritis

Siti Nurfitria; Diana Nurus Sholehah

Siti Nurfitria Program Studi Psikologi Fakultas Ilmu Sosial dan Ilmu Budaya, Universitas Trunojoyo
Diana Nurus Sholehah Program Studi Agroteknologi Fakultas Pertanian, Universitas Trunojoyo

Abstract

Background: Acute arthritis gout is a form of arthritis caused by deposits of crystalline monosodium urate (MSU) in joints, bones and soft tissues. This disease can cause a large socioeconomic impact considering gout attacks the average young adult upwards that in fact is a productive age. Objective: This study aims to prove the effect of breadfruit ethanol extract (Artocarpus communis) on local inflammation through decrease of IL-6 from mice of gout arthritis model. Method: The type and design of this research is laboratory experimental research using post test only control group design. 20 Balb-c female mice were modeled on gout arthritis by injecting MSU dissolved in PBS intraarticularly on tibio-tarsal joint (ankle) and then divided into 5 groups, ie 1 normal group, 1 group of gout arthritis mice who were not given ethanol extract leaves of breadfruit, and 3 groups of treatment that is mice gout arthritis model which was given the extract of ethanol leaves of breadfruit with dose respectively 1.25; 2.5 and 3.75 g / kg bb for 2 weeks. Result: The results showed that the giving of breadfruit ethanol extract (Artocarpus communis) influenced local inflammation in gout arthritis (p = 0,001). The results showed that ethanol extract of breadfruit leaves was able to decrease IL-6 in the synovial fluid of experimental animals and there was significant difference of IL-6 concentration in the five groups of mice (p = 0.000). The results also showed a strong correlation between local inflammation and IL-6 levels (P = 0.000; r = -0.839). Conclusion: From the above it can be concluded that the ability of breadfruit ethanol extract decreased local inflammation through decreased levels of IL-6 in gout arthritis model.

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